Accession Number : ADA259102


Title :   Trichloromelamine 14-Day Range Finding and 90-Day Subchronic Studies in Rats. 3 August 1988 - 17 January 1989. Phase 2


Descriptive Note : Toxicological study 3 Aug 88-17 Jan 89, (Final),


Corporate Author : ARMY ENVIRONMENTAL HYGIENE AGENCY ABERDEEN PROVING GROUND MD


Personal Author(s) : Michie, Mark ; Angerhofer, Richard A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a259102.pdf


Report Date : 13 Nov 1992


Pagination or Media Count : 72


Abstract : The subchronic study examined the toxicity of the food service disinfectant trichloromelamine (TCM) in rats following oral administration-for 90 days. Associated with the administration of TCM in rats were lesions in the stomach and trachea, while also causing engorgement of the small blood vessels of the adrenals, brain, kidneys, liver, lung and pituitary. The no observed adverse effect level in the 90-day study was 30 mg/kg/day. Trichloromelamine should be considered moderately toxic when ingested acutely, and continuous ingestion could cause serious health effects.... Trichloromelamine, Toxicity, 14-Day, 90-Day.


Descriptors :   *TOXICITY , BRAIN , RATS , LIVER , LESIONS , TRACHEA , FOOD SERVICE , STOMACH , KIDNEYS , BLOOD VESSELS , LUNG , HEALTH


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE