Accession Number : ADA258668
Title : Experimental Treatment of Burn Victims in Field Hospitals.
Descriptive Note : Final rept. 30 Sep 87-29 Nov 91,
Corporate Author : MASSACHUSETTS INST OF TECH CAMBRIDGE
Personal Author(s) : Yannas, Ioannis V
Report Date : 28 Aug 1992
Pagination or Media Count : 67
Abstract : The research effort centered on the development of an experimental treatment of burn victims. The specific objective was the development of an immediately graftable, nonimmunogenic material which supplies the function both of the dermis and the epidermis over an indefinite period. The objective was largely accomplished in the guinea Dig model. The successful design was based on a biologically specific analog of extracellular matrix (ECM) which was seeded with foreign epidermal cells. A demonstrated rejection model was used together with a staining technique for identification of cells involved in graft rejection. the transplantation of epidermal cells using the ECM analog showed no evidence of rejection in 12 out of 14 grafts. Long term observations showed gross and histologic evidence of synthesis of new physiologic dermis and epidermis (no hair follicles). It is suggested that these grafts can be used to avoid problems of autologous tissue availability.
Descriptors : *BURNS(INJURIES) , *SURGICAL TRANSPLANTATION , FUNCTIONS , TISSUES(BIOLOGY) , FOREIGN , MODELS , SYNTHESIS , OBSERVATION , IDENTIFICATION , GUINEA PIGS , HAIR , DERMATOLOGY , SKIN GRAFTS , IMMUNOLOGY , HOSPITALS , CELLS(BIOLOGY) , TRAUMA , HISTOLOGY , EPIDERMIS
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE