Accession Number : ADA258185


Title :   Systemic and Pulmonary Hypertension After Resuscitation with Cell-Free Hemoglobin


Descriptive Note : Final rept,


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA DIV OF BLOOD RESEARCH


Personal Author(s) : Hess, John R ; Macdonald, Victor W ; Brinkley, William D


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a258185.pdf


Report Date : Jul 1992


Pagination or Media Count : 37


Abstract : Human hemoglobin (Hb) and hemoglobin cross-linked between the alpha subunits with bis-(3,5-dibromosalicyl)fumarate (aaHb) were used to treat hemorrhagic shock in water-deprived swine. Water was withheld for 48 hours to induce a 10% loss of body mass, and 25 ml/kg of blood was removed over one hour to produce circulatory shock. Swine were resuscitated with (1) Hb,, (2) aaHb, (3) human serum albumin, or (4) Ringer's lactate. Mild high-output renal failure was observed in the non-crosslinked Hb-treated animals but not in other groups. Swine treated with Hb and aaHb had increases in plasma creatine kinase and lactate dehydrogenase activity that was resolved by seven days. Both Hb- and AAHb treated swine displayed marked elevations of mean blood pressure in the systemic (39+6 Torr) and pulmonary (20+6 Torr) circulations that continued over three hours and were associated with reduced cardiac output and a doubling of the systemic and pulmonary vascular resistance. oxygen delivery was equivalent and the rate of correction of the lactic acidosis was equal in all groups.


Descriptors :   *CELLS , *HEMOGLOBIN , *HEMORRHAGIC SHOCK , *RESUSCITATION , *PULMONARY HYPERTENSION , OUTPUT , TOXICITY , RESISTANCE , RATES , CROSSLINKING(CHEMISTRY) , PRESSURE , ERYTHROCYTES , BLOOD SUBSTITUTES , BLOOD PRESSURE , PHOSPHATES , BLOOD VOLUME , LEUKOCYTES , CORRECTIONS , ALBUMINS , BLOOD , BODIES , PHOSPHORUS TRANSFERASES , DEHYDROGENASES , CREATINE , ACIDOSIS , LACTATES , SERUM ALBUMIN , HYPERTENSION , ELEVATION , ANIMALS , SHOCK , OXYGEN , FAILURE , MASS , HUMANS


Subject Categories : Biology
      Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE