Accession Number : ADA257408
Title : Emesis in Ferrets Following Exposure to Different Types of Radiation: A Dose-Response Study
Descriptive Note : Scientific rept.
Corporate Author : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD
Personal Author(s) : Rabin, Bernard M ; Hunt, Walter A ; Wilson, Matthew E ; Joseph, James A
Report Date : Aug 1992
Pagination or Media Count : 6
Abstract : Ferrets were exposed to gamma rays (60Co), fission neutrons, high-energy electrons (18.5 MeV) or iron particles (56Fe, 600 MeV/amu) in order to establish the dose-response relationships for emesis following exposure to different types of radiation. The results showed that the mean effective doses (ED50s) for iron particles (35 cGy) and neutrons (40 cGy) were similar. High-energy electrons were the least effective radiation, with an ED50 of 138 cGy. Gamma rays, with an ED50 of 95 cGy, showed an intermediate effectiveness. The results suggest that the relative effectiveness of different types of radiation generally increases with an increase in linear energy transfer (LET), although LET is not completely predictive of relative behavioral effectiveness.
Descriptors : *RADIATION , *EMESIS , HIGH ENERGY , PARTICLES , GAMMA RAYS , LETHALITY , NEUTRONS , FISSION NEUTRONS , FISSION , IRON , ENERGY TRANSFER , RESPONSE
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE