Accession Number : ADA257345


Title :   Evaluation of Dried Storage of Platelets and RBC for Transfusion: Lyophilization and other Dehydration Techniques.


Descriptive Note : Final technical rept. 1 Feb 89-31 Jul 92,


Corporate Author : EAST CAROLINA UNIV SCHOOL OF MEDICINE GREENVILLE NC


Personal Author(s) : Bode, Arthur P ; Read, Marjorie S ; Reddick, Robert L ; Holme, Stein ; Heaton, W A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a257345.pdf


Report Date : 02 Nov 1992


Pagination or Media Count : 23


Abstract : This project was put forth to meet the needs expressed by the Naval Medical Research and Development Command for long-term dried storage of human blood cells for transfusion support of combat casualty care. OUr main focus was on preparation of platelets for successful dehydration, storage, and rehydration without substantial compromise of hemostatic function. The primary technology was developed as an extension of a pre-existing protocol for drying fixed platelets as a diagnostic product, but many alternative approaches were also tried on an empirical basis. None of these methods had been previously applied to the development of a transfusion product.


Descriptors :   *BLOOD TRANSFUSION , *BLOOD CELLS , TEST AND EVALUATION , PERFORMANCE(HUMAN) , IN VITRO ANALYSIS , LYOPHILIZATION , MEDICAL RESEARCH , DEHYDRATION , LABORATORY ANIMALS , DIAGNOSTIC AGENTS


Subject Categories : Medicine and Medical Research
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE