Accession Number : ADA256419
Title : Antiviral Drugs: Molecular Modeling and QSAR.
Descriptive Note : Final rept. 1 Mar 88-14 Apr 89,
Corporate Author : NAVAL RESEARCH LAB WASHINGTON DC
Personal Author(s) : Ward, Keith B
Report Date : 10 Dec 1990
Pagination or Media Count : 28
Abstract : In order to provide guidance for a USAMRIID drug development program, an assessment was made of the major needs of USAMRIID in this field. Methods and techniques were implemented to fulfill these requirements. Because of the paucity and lack of quality of objective assesment of antiviral activity of compounds being explored, a major effort involved developing novel methodology that could deal successfully with these data. Only when LSM workers were granted free access to computerized data bases developed for USAMRIID by Techna Associates was progress forthcoming on the effort. Software was developed using the Atoms Pairs method to describe the topology of compounds under investigation. This has produced a method to identify lead compounds, to identify cogenes to active compounds not in the Technq database and to identify new types of compounds not previously investigated for antiviral activity. Drug discovery, QSAR, Antiviral drugs, Atom pairs method, RA 1.
Descriptors : *ANTIVIRAL AGENTS , DATA BASES , REQUIREMENTS , METHODOLOGY , QUALITY , GUIDANCE , DRUGS
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE