Accession Number : ADA256270


Title :   Evaluation of N-Methyl-n'-Nitroguanidine in Short-Term Genetic Toxicity Tests.


Descriptive Note : Final rept. 11 Jun-12 Nov 1991,


Corporate Author : MANTECH ENVIRONMENTAL TECHNOLOGY INC DAYTON OH


Personal Author(s) : Godin, C S ; Thilagar, A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a256270.pdf


Report Date : Dec 1991


Pagination or Media Count : 29


Abstract : N-Methyl-N'-nitroguanidine (MNG) is being considered as a component of Air Force explosive formulations. This chemical was evaluated in several bioassays to assess its potential genotoxic activity. The assays conducted were the Ames Salmonella/microsomal assay, the Chinese hamster ovary/hypoxanthine- guanine phosphoribosyltransferase forward mutation assay, and the mouse in vivo bone marrow micronucleus assay. Both in vitro assays were conducted in the presence and absence of S9 metabolic activation enzymes. The results of the three genetic tests indicated that MNG does not interact with genetic material. Also, no toxicity was observed for very high dose levels. These assays would therefore predict essentially no genotoxic risk from exposure to MNG. Ames Assay, Forward Mutation Assay, Genotoxicity, N-Methyl-N'-Nitroguanidine, Mouse Micronucleus Assay.


Descriptors :   *TOXICITY , *GENETICS , *BONE MARROW , *NITROGUANIDINE , TEST AND EVALUATION , AIR FORCE , ACTIVATION , RISK , ENZYMES , EXPLOSIVES , SALMONELLA , SALMONELLA TYPHIMURIUM , OVARIES , GUANINE , BONES , HAMSTERS , IN VITRO ANALYSIS , MUTATIONS , FORMULATIONS , AIR FORCE RESEARCH , AIR , CHEMICALS , MATERIALS


Subject Categories : Medicine and Medical Research
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE