Accession Number : ADA256238
Title : Pharmacokinetic Modeling of Trivalent and Hexavalent Chromium Based on Ingestion and Inhalation of Soluble Chromium Compounds.
Descriptive Note : Final rept. Jun 1990-Dec 1991,
Corporate Author : CINCINNATI UNIV OH DEPT OF ENVIRONMENTAL HEALTH
Personal Author(s) : O'Flaherty, Ellen J ; Radike, Martha J
Report Date : Dec 1991
Pagination or Media Count : 139
Abstract : A physiologically-based model of chromium disposition in the rat has been developed. Absorption, distribution, and excretion of chromium are superimposed on a general physiological model of rat growth and development. The model considers both Cr (VI) and Cr (III), administered either orally or by inhalation. It incorporates reduction of Cr (VI) to Cr (III) in all tissues including the lung and the GI tract. Chromium is cleared from the lung by systemic absorption and by mucociliary clearance into the GI tract. Parameter values are based on literature data and on the results of a concurrent experimental study in which rats were given either Cr (111) or Cr (VI) either in the drinking water or by inhalation. Blood, tissue, urine, and fecal chromium levels were monitored on days 2, 5, 10, 20, and 40 of the 40-day exposure period, and at 20 days postexposure. Cr(VI), Cr(III), Oral exposure, Inhalation exposure, Physiologically-based model.
Descriptors : *MODELS , *PHARMACOKINETICS , *CHROMIUM COMPOUNDS , TISSUES(BIOLOGY) , RATS , DISTRIBUTION , PARAMETERS , WATER , TOXICITY , CHEMICAL ANALYSIS , INGESTION(PHYSIOLOGY) , EXCRETION , INHALATION , CLEARANCES , URINE , BLOOD , SITES , REDUCTION , DRINKING WATER , LUNG , CHROMIUM , VALUE , ABSORPTION
Subject Categories : Pharmacology
Distribution Statement : APPROVED FOR PUBLIC RELEASE