Accession Number : ADA256170
Title : Cytotoxicity of Selected Cesium and Zinc Oxythiomolybdates In Vitro.
Descriptive Note : Final rept. Jun 1991-Jan 1992,
Corporate Author : ARMSTRONG LAB WRIGHT-PATTERSON AFB OH
Personal Author(s) : DelRaso, N R ; Channel, S R
Report Date : Jan 1992
Pagination or Media Count : 28
Abstract : The toxicity of complex oxythiomolybdate (OTM) compounds, solid lubricants under development by the Air Force, was determined. The OTMs investigated were unburned and burned (650 deg C) cesium oxytrithiomolybdate (COTM), zinc oxydithiomolybdate (ZODM) and zinc oxytrithiomolybdate (ZOTM), respectively. An in vitro approach was employed using the rat liver cell line WB 344. Lactate dehydrogenase enzyme leakage (LDH), cellular esterase enzyme activity and DNA synthesis analysis were measured to rank-order the toxicity of the test compounds. The ZODM compounds (at equimolar concentrations; unburned and burned) were the only ones found not to produce any effects on WB 344 cells. While unburned COTM and ZOTM compounds were found to exhibit some cytotoxic effects and depress cellular DNA, the cytotoxic effects and DNA depression were more severe with COTM exposures. The burning of the ZOTM compound did not alter it's effects on the WB 344 cells. However, burning of the COTM compound was found to reduce its cytotoxic and DNA effects when compared to the unburned COTM exposures. Based on these results, the relative rank-order of toxicity of the three OTM's tested (unburned and burned) was COTM ZOTM ZODM. Cesium oxytrithiomolybdate, RAT liver cell line WP 344, Zinc oxytrithiomolbdate.
Descriptors : *CESIUM , *IN VITRO ANALYSIS , *ZINC , TEST AND EVALUATION , AIR FORCE , RATS , SYNTHESIS , LIVER , LACTATES , ESTERASES , DEHYDROGENASES , APPROACH , LUBRICANTS , SOLID LUBRICANTS , COMBUSTION , CELLS , TOXICITY , ENZYMES , SOLIDS
Subject Categories : Biochemistry
Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE