Accession Number : ADA255818


Title :   Cholinergic Neurotransmission in the Mammalian Retina.


Descriptive Note : Annual summary rept. 30 Sep 1985-31 Dec 1987,


Corporate Author : WAYNE STATE UNIV DETROIT MI


Personal Author(s) : Pourcho, Roberta G


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a255818.pdf


Report Date : 30 Jan 1988


Pagination or Media Count : 35


Abstract : The cholinergic cells in the retina consist of matching subpopulations of amacrine and displaced amacrine cells which ramify narrowly in the inner plexiform layer (IPL). Previous cytochemical studies revealed that the hydrolytic enzyme acetylcholinesterase (AChE), which terminates the action of acetylcholine (ACh), is more widespread in its distribution than the enzyme choline acetyltransferase (ChAT), which is responsible for ACh synthesis. Cytochemical techniques were utilized to further define the sites of cholinergic interaction in the retina. Autoradiographic studies showed that both the muscarinic receptor ligand (3H)propylbenzilyl choline mustard and the putative nicotinic receptor ligand (3H)alpha-bungarotoxin bind preferentially in the IPL. RAV; Lab animals; morphology; retina; neurotransmitters; acetylcholine; organophosphates; chemical defense.


Descriptors :   *RETINA , *NEUROTRANSMITTERS , *CHOLINE ACETYLTRANSFERASE , DISTRIBUTION , INTERACTIONS , CHEMICALS , LAYERS , CELLS , MATCHING , MUSCARINE , ACETYLCHOLINE , ORGANOPHOSPHATES , ACETYLCHOLINESTERASE , ENZYMES , CHOLINES , SITES , MORPHOLOGY , LIGANDS , ANIMALS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE