Accession Number : ADA255480


Title :   A Comparative Study Regarding the Association of Alpha-2u Globulin with the with the Nephrotoxic Mechanism of Certain Petroleum-Based Air Force Fuels.


Descriptive Note : Annual Technical rept. 1 Jul 1991-30 Jun 1992,


Corporate Author : ILLINOIS UNIV AT URBANA DEPT OF VETERINARY BIOSCIENCES


Personal Author(s) : Eurell, Thomas E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a255480.pdf


Report Date : Aug 1992


Pagination or Media Count : 6


Abstract : Adult male rats have a strain, dose, and time-dependent renal proximal tubular degeneration induced by certain hydrocarbon compounds. We are using rat strain variation (Fisher 344 and NCI Black Reiter) and different hydrocarbon compounds (JP-4, JP-8, decalin and trimethylpentane) to investigate the hydrocarbon-induced nephrotoxic response. Histochemical and morphometric evaluation of NCI-Black Reiter rats exposed to JP-8 indicate that this strain undergoes an intermediate form of the hydrocarbon-induced nephrotoxicity when compared to the albino Fisher 344 strain. The intermediate nephrotoxic response of the NCI-Black Reiter rat is characterized by approximately a two-fold increase in the number of acid phosphatase reactive lysosomes in renal tubular cells. The NBR rats did not demonstrate an increase in the size of the individual hlysosomes, however, a characteristic lysosomal aggregation pattern occurred in renal tubular cells following hydrocarbon exposure.


Descriptors :   *TOXICITY , *GLOBULINS , *ALPHA GLOBULIN , RATS , TIME , FUELS , HYDROCARBONS , PATTERNS , NUMBERS , CRUDE OIL , ACID PHOSPHATASE , PHOSPHATASES , HISTOCHEMISTRY , ACIDS , ADULTS , MALES , STRAINS(BIOLOGY) , RESPONSE , VARIATIONS , CELLS


Subject Categories : Biochemistry
      Toxicology
      Fuels


Distribution Statement : APPROVED FOR PUBLIC RELEASE