Accession Number : ADA255257


Title :   The 3D Structure of Some Diarrheal Causing Bacterial Toxins


Descriptive Note : Final rept. 1 Jul 1987-30 Jun 1992, Annual rept.


Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER PITTSBURGH PA


Personal Author(s) : Sax, Martin


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a255257.pdf


Report Date : 23 Jul 1992


Pagination or Media Count : 18


Abstract : The major objective of this research project, to determine the 3D crystal structure of the staphyloccal enterotoxin Beta (SEB), was attained. The structure was solved to a resolution of 2.5 A, and the final result has been submitted for publication to the scientific journal, Nature. The T cell receptor binding site was identified and was demonstrated in a sterically detailed manner with the aid of knowledge obtained independently in a mutational analysis. Regions implicated in the binding of SEB to MHC class II molecules also were elucidated in steric detail. All of the SEs (A to E inclusive) are predicted to s the SEB main chain fold. Staphylococcal enterotoxins; 3D structures; X-ray diffraction; Protein crystallography; Superantigen; RA 4.


Descriptors :   *DIARRHEA , *BACTERIAL TOXINS , CRYSTAL STRUCTURE , X RAY DIFFRACTION , ENTEROTOXINS , MOLECULAR STRUCTURE , IMMUNOLOGY , CRYSTALLOGRAPHY , STAPHYLOCOCCUS


Subject Categories : Medicine and Medical Research
      Toxicology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE