Accession Number : ADA254594
Title : Ultrasound Assisted Assay for Toxins in Blood. SBIR 90.I (A90-180).
Descriptive Note : Final rept. 2 Apr-2 Oct 90,
Corporate Author : TECHNICAL RESEARCH ASSOCIATES INC SALT LAKE CITY UT
Personal Author(s) : Baker, Charles D ; Sanders, Clifton G ; Borromeo, Peter
Report Date : 02 Oct 1990
Pagination or Media Count : 21
Abstract : Work was carried out to determine the feasibility for a spectroscopic analysis of saxitoxin in whole blood samples. Modifications of standard chemical assays were to be used in conjunction with TRA's ultrasonic blood separation technology to form an analytical detection system that is suitable for field use by minimally trained personnel. The chemical assay method was successfully to generate a fluorescent saxitoxin derivative using solid oxidants in a stable dry formulation. Direct detection of low levels of this analyte in plasma was precluded by interference from the plasma matrix. Chemical Assay, Oxidants, Spectroscopic Detection, RAI, SBIR Phase I, Ultrasound, Fluorimetry.
Descriptors : *ULTRASONICS , *CHOLESTEROL , *BLOOD PLASMA , DETECTION , CHEMICALS , MODIFICATION , FORMULATIONS , STANDARDS , SEPARATION , WORK , BLOOD CIRCULATION , BLOOD , FLUOROMETERS , PERSONNEL , OXIDIZERS , INTERFERENCE , OXIDATION , SOLIDS , PHASE , FEASIBILITY STUDIES
Subject Categories : Biochemistry
Anatomy and Physiology
Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE