Accession Number : ADA254508
Title : Longterm Follow-Up of Patients in CSP 298 'Treatment of Patients with Acquired Deficiency Syndrome (AIDS) and AIDS Related Complex'.
Descriptive Note : Annual rept. 1 Apr 91-30 Mar 92,
Corporate Author : VETERANS ADMINISTRATION MEDICAL CENTER NEW YORK
Personal Author(s) : Simberkoff, M S ; Hamilton, J
Report Date : 01 Apr 1992
Pagination or Media Count : 21
Abstract : In order to determine whether there is a long-term benefit to initial versus delayed treatment with AZT, a long-term follow-up study is being conducted for patients enrolled in a USAMRDC funded, randomized trial of early versus later zidovudine (AZT) therapy in patients with symptomatic HIV infection and CD4 counts between 200 and 500 cells/cmm. At the present time, the study demonstrates no survival benefits, no reduction in the number or rate of progression to AIDS, no improvements in the quality of life in one or the other treatment arm, and some emergence of low level resistance in patients treated with AZT for more than one year. These studies are continuing with approximately 73% of the original study population. RA 1; A2T; Drug Trials; HIV; Veterans; Follow-up.
Descriptors : *PATIENTS , *HUMAN IMMUNODEFICIENCY VIRUSES , *ACQUIRED IMMUNE DEFICIENCY SYNDROME , CELLS , TOXICITY , RESISTANCE , RATES , POPULATION , DRUGS , BENEFITS , VIRAL PNEUMONIA , PLACEBOS , NUMBERS , INFECTIOUS DISEASES , REDUCTION , QUALITY , LOW LEVEL , THERAPY
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE