Accession Number : ADA254096


Title :   World Reference Center for Arboviruses.


Descriptive Note : Annual rept. 9 Feb 1991-8 Feb 1992,


Corporate Author : YALE UNIV NEW HAVEN CT SCHOOL OF MEDICINE


Personal Author(s) : Shope, Robert E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a254096.pdf


Report Date : 08 Mar 1992


Pagination or Media Count : 18


Abstract : The major finding in 1991 was the discovery of a new arenavirus Guanarito, causative agent of Venezuelan hemorrhagic fever. The study of 15 patients in Portuguesa State, Venezuela confirmed the clinical syndrome of hemorrhagic fever, and the high case fatality rate (9/15). Serological diagnostic tests were developed including IgM capture ELISA. Initial observations in the field indicated a probable rodent-borne epidemiology. Other findings included a new genotype of Japanese encephalitis virus in Indonesia, and the development of recombinant vaccinia viruses excreting subviral particles that immunized mice to Japanese encephalitis and yellow fever viruses. The reference center distributed arboviral reagents to laboratories in the United States and in 9 other countries.


Descriptors :   *HEMORRHAGIC FEVERS , *EPIDEMIOLOGY , *VACCINIA VIRUS , *ARBOVIRUSES , TEST AND EVALUATION , UNITED STATES , OBSERVATION , RATES , SIGNS AND SYMPTOMS , DEOXYRIBONUCLEIC ACIDS , VIRUS DISEASES , JAPANESE ENCEPHALITIS VIRUSES , JAPANESE ENCEPHALITIS , YELLOW FEVER , INDONESIA , DENGUE VIRUS , VENEZUELA , FEVERS , ENCEPHALITIS , DIAGNOSIS(MEDICINE) , PARTICLES , LABORATORIES , PATIENTS , MICE , RODENTS


Subject Categories : Biology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE