Accession Number : ADA254091


Title :   Development of Methods for Detection of Lipid Peroxidation Products in Human Tissues Generated by Environmental Toxins.


Descriptive Note : Annual rept. 1 Jul 91-30 Jun 92,


Corporate Author : MONTANA STATE UNIV BOZEMAN DEPT OF CHEMISTRY


Personal Author(s) : VAN Kuijk, Frederik J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a254091.pdf


Report Date : 30 Jun 1992


Pagination or Media Count : 4


Abstract : Research to date has resulted in the synthesis of isotope labelled 9- oxononanoate and the development of generic methods for the introduction of a variety of isotopic labels in the 4-hydroxyalkenals. Additional studies demonstrated that 4-hydroxyalkenals could be released from protein sulfhydryl groups. Future studies will investigate whether 4-hyroxynonenal binds to the sulfhydral groups on human rhodopsin interfering with the visual transduction process.


Descriptors :   *PROTEINS , *EYE PIGMENTS , DETECTION , HUMANS , ISOTOPES , LABELS , SYNTHESIS , LIPIDS


Subject Categories : Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE