Accession Number : ADA254091
Title : Development of Methods for Detection of Lipid Peroxidation Products in Human Tissues Generated by Environmental Toxins.
Descriptive Note : Annual rept. 1 Jul 91-30 Jun 92,
Corporate Author : MONTANA STATE UNIV BOZEMAN DEPT OF CHEMISTRY
Personal Author(s) : VAN Kuijk, Frederik J
Report Date : 30 Jun 1992
Pagination or Media Count : 4
Abstract : Research to date has resulted in the synthesis of isotope labelled 9- oxononanoate and the development of generic methods for the introduction of a variety of isotopic labels in the 4-hydroxyalkenals. Additional studies demonstrated that 4-hydroxyalkenals could be released from protein sulfhydryl groups. Future studies will investigate whether 4-hyroxynonenal binds to the sulfhydral groups on human rhodopsin interfering with the visual transduction process.
Descriptors : *PROTEINS , *EYE PIGMENTS , DETECTION , HUMANS , ISOTOPES , LABELS , SYNTHESIS , LIPIDS
Subject Categories : Biology
Distribution Statement : APPROVED FOR PUBLIC RELEASE