Accession Number : ADA254066
Title : Cellular Analogs of Operant Behavior.
Descriptive Note : Final technical rept. 1 Dec 1988-31 May 1992,
Corporate Author : CALIFORNIA UNIV IRVINE
Personal Author(s) : Stein, Larry ; Belluzzi, James D ; McAfee, Donald
Report Date : 31 Jul 1992
Pagination or Media Count : 186
Abstract : Using the hippocampal-slice preparation, we attempted to demonstrate for the first time the operant conditioning of pyramidal cell bursting activity using local micropressure applications of transmitters and drugs as reinforcement; the same injections administered independently of bursting provided a control for direct pharmacological stimulation or facilitation of neuronal firing. The results suggested that the spontaneous activity of individual CA1 pyramidal cells may be reinforced with burst-contingent injections of dopamine D1 and D2 and cannabinoid receptor agonists, whereas CA3 bursting may be reinforced with mu-opioid agonists. Many of these indications of cellular operant conditioning were confirmed at the behavioral level in parallel studies of hippocampal and intravenous self-administration. The results are consistent with the hypothesis that, in the brain slice experiments, drug injections facilitated hippocampal bursting by a cellular mechanism analogous to behavioral reinforcement.
Descriptors : *DRUGS , *DOPAMINE , *HIPPOCAMPUS , *PHARMACOLOGY , *OPIUM ALKALOIDS , CONTROL , MANAGEMENT , PREPARATION , BRAIN , CELLS , RUPTURE , TIME , PLASTIC PROPERTIES , ANALOGS , BEHAVIOR
Subject Categories : Biology
Distribution Statement : APPROVED FOR PUBLIC RELEASE