Accession Number : ADA254066


Title :   Cellular Analogs of Operant Behavior.


Descriptive Note : Final technical rept. 1 Dec 1988-31 May 1992,


Corporate Author : CALIFORNIA UNIV IRVINE


Personal Author(s) : Stein, Larry ; Belluzzi, James D ; McAfee, Donald


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a254066.pdf


Report Date : 31 Jul 1992


Pagination or Media Count : 186


Abstract : Using the hippocampal-slice preparation, we attempted to demonstrate for the first time the operant conditioning of pyramidal cell bursting activity using local micropressure applications of transmitters and drugs as reinforcement; the same injections administered independently of bursting provided a control for direct pharmacological stimulation or facilitation of neuronal firing. The results suggested that the spontaneous activity of individual CA1 pyramidal cells may be reinforced with burst-contingent injections of dopamine D1 and D2 and cannabinoid receptor agonists, whereas CA3 bursting may be reinforced with mu-opioid agonists. Many of these indications of cellular operant conditioning were confirmed at the behavioral level in parallel studies of hippocampal and intravenous self-administration. The results are consistent with the hypothesis that, in the brain slice experiments, drug injections facilitated hippocampal bursting by a cellular mechanism analogous to behavioral reinforcement.


Descriptors :   *DRUGS , *DOPAMINE , *HIPPOCAMPUS , *PHARMACOLOGY , *OPIUM ALKALOIDS , CONTROL , MANAGEMENT , PREPARATION , BRAIN , CELLS , RUPTURE , TIME , PLASTIC PROPERTIES , ANALOGS , BEHAVIOR


Subject Categories : Biology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE