Accession Number : ADA253312


Title :   Molecular Genetic Analysis of Parasite Survival in P. falciparum Malaria.


Descriptive Note : Annual rept. 1 Nov 89-30 Nov 90,


Corporate Author : MEMORIAL SLOAN-KETTERING CANCER CENTER NEW YORK


Personal Author(s) : Ravetch, Jeffrey V


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a253312.pdf


Report Date : 15 Mar 1991


Pagination or Media Count : 57


Abstract : The human malaria parasite evades the protective mechanisms of its host through a complex variety of strategies. Extensive genetic variation is thought to contribute to the mechanism by which the parasite survives within its vertebrate host. Recent studies have focussed on the mechanism of genetic variability of the parasite. Pronounced chromosomal size variations are observed between different geographical isolates of the parasite and during mitotic growth of the parasite in culture. Several of these chromosomal polymorphisms have been characterized and found to be the result of chromosome breakage followed by the healing of these broken ends by the addition of telomere repeats, resulting in large distal deletions and truncated chromosomes. Only the chromosomal fragments associated with centromere containing elements are mitotically stable and retained. Further insight into the molecular mechanism of this process was obtained by the analysis of the RESA inversion/breakage on chromosome 1. In at least one case, this process resulted in a transcriptional Malaria, Vaccine, Molecular biology, Merozoite, Erythrocyte, Recombinant DNA, RA 1.


Descriptors :   *MOLECULAR BIOLOGY , *PARASITES , *GENETICS , *PLASMODIUM FALCIPARUM , STRATEGY , SURVIVABILITY , BIOLOGY , HUMANS , ERYTHROCYTES , MEROZOITES , HEALING , POLYMORPHISM , VACCINES , CULTURE , IMMUNITY , MALARIA , INVERSION , CHROMOSOMES , VARIATIONS , VERTEBRATES


Subject Categories : Genetic Engineering and Molecular Biology
      Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE