Animal Models of Ionizing Radiation Damage
Technical rept. 18 May 88-18 May 91,
PATHOLOGY ASSOCIATES INC FREDERICK MD
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This report is a survey of the English language literature of radiation biology between 1947 and 1987, for the purpose of compiling a literature base on the effects of radiation on animals, which have yielded results that can expand our knowledge about similar radiation effects on human beings. Articles were sought that reported exposure of adult mammals to external sources of ionizing radiation, having endpoints that included effects on the brain, the spinal cord, and behavior the gastrointestinal, endocrine, and cardiovascular systems and the hematopoietic and immune systems. Effects of interest were those that occurred within the first 12 months after exposure. The survey does not include articles reporting chronic or long term delayed effects of radiation unless they provided insight into mechanisms of morphological and or functional derangement. Information presented in the report is divided into subtopics i.e., Brain-Morphological Changes. The brief introduction to each subtopic is followed by a condensed description of representative reports and a short summary of conclusions based on those reports. The articles reviewed are appended as a Bibliography, arranged alphabetically within subtopics.
- Anatomy and Physiology