Accession Number : ADA243387


Title :   The Effects of Storage on Irradiated Red Blood Cells: An In Vitro and In Vivo Study


Descriptive Note : Master's thesis,


Corporate Author : AIR FORCE INST OF TECH WRIGHT-PATTERSON AFB OH


Personal Author(s) : Knoll, Susan E


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a243387.pdf


Report Date : Aug 1991


Pagination or Media Count : 111


Abstract : Irradiation of red blood cell units has recently become a topic of special concern as the result of increasing reports of graft versus host disease in immunocompetent blood transfusion recipients. This study was designed to evaluate the potassium elevations observed in stored irradiated red blood cells and to evaluate the in vivo survival of stored irradiated red blood cells using a dog model. In the in vitro study ten units of human CPDA-1 packed red blood cells were made into paired aliquots; one aliquot of each pair was irradiated with 3000 rads of gamma radiation and the potassium content measured at points throughout 35 days of storage. A significant increase in potassium levels in the irradiated aliquots was observed from the first day after irradiation and continued through the entire storage period.


Descriptors :   *MODELS , DISEASES , SURVIVAL(GENERAL) , IN VITRO ANALYSIS , GAMMA RAYS , IRRADIATION , STORAGE , ELEVATION , IN VIVO ANALYSIS , ERYTHROCYTES , POTASSIUM , TRANSPLANTATION , DOGS , HOSTS(BIOLOGY) , REPORTS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE