Accession Number : ADA240121


Title :   Synaptic Plasticity and Memory Formation


Descriptive Note : Annual technical rept. 15 May 1990-14 May 1991


Corporate Author : CALIFORNIA UNIV IRVINE CENTER FOR THE NEUROBIOLOGY OF LEARNING AND MEMORY


Personal Author(s) : Lynch, Gary


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a240121.pdf


Report Date : 14 Jun 1991


Pagination or Media Count : 6


Abstract : The goal of the project is to define the mechanisms responsible for inducing, expressing, and stabilizing long-term synaptic potentiation (LTP), a form of physiological plasticity that is likely to be responsible for the encoding of memory in telencephalic networks. Studies in the past year defined the cellular changes likely to be responsible for expressions. The nootropic ('cognitive enhancing') drug aniracetam prolongs the open time of post-synaptic receptors mediating fast synaptic transmission. LTP changes the effect of the drug on synaptic responses in hippocampus; manipulations that enhance responses by increasing release do not interact with the drug. By far the most plausible explanation of this result is that LTP modifies receptors. This conclusion is supported by negative results from experiments testing the hypotheses that LTP is due to changes in release, receptor number, or spine resistance.


Descriptors :   *DRUGS , *MEMORY(PSYCHOLOGY) , *SYNAPSE , RESISTANCE , LONG RANGE(TIME) , TIME , TRANSMITTANCE , MEMORY DEVICES , CODING , RESPONSE , PLASTIC PROPERTIES , PHYSIOLOGY , HYPOTHESES , SENSE ORGANS , SPINAL COLUMN , CELLS , HIPPOCAMPUS , TEST AND EVALUATION , STABILIZATION


Subject Categories : Psychology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE