Accession Number : ADA236352


Title :   Acute Toxicity Evaluation of Nitroaromatic Compounds


Descriptive Note : Final rept. 29 Sep 1989-29 Sep 1990,


Corporate Author : TOXIKON CORP WOBURN MA


Personal Author(s) : FitzGerald, George B ; Austin, Amy ; DiGuilio, Nancy


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a236352.pdf


Report Date : Mar 1991


Pagination or Media Count : 76


Abstract : The nitroaromatics 1,3-dinitrobenzene (DNB), 1,2,5-trinitrobenaene (TNB) and N-methyl-n,2,4,6-tetranitroaniline (tetryl) have been detected as environmental contaminants of water and soil near production waste sites and at military test grounds. Acute toxicity evaluations were carried out with these compounds to develop environmental and health effects criteria. Dermal and eye irritation tests and acute dermal sensitization (Buehler) tests in guinea pigs were conducted according to EPA standard protocols. The sensitization tests showed that DNB and tetryl are not skin sensitizers while TNB caused a mild allergic reaction. None of these compounds produced skin irritation but positive (DNB) to severe (TNB, tetryl) eye irritation potentials were observed.


Descriptors :   *TEST AND EVALUATION , WATER , HEALTH , TOXICITY , SITES , ENVIRONMENTAL IMPACT , STANDARDS , CONTAMINANTS , AROMATIC COMPOUNDS , EYE , WASTES , RESPONSE(BIOLOGY) , SKIN(ANATOMY) , NITROGEN COMPOUNDS , GUINEA PIGS , SENSITIZING , TETRYL , ALLERGIC DISEASES , IRRITATION , ENVIRONMENTS


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE