Accession Number : ADA236325


Title :   Bacteria-Phagocyte Interactions: Emerging Tactics in an Ancient Rivalry


Corporate Author : WALTER REED ARMY INST OF RESEARCH WASHINGTON DC


Personal Author(s) : Cross, Alan S ; Kelly, Niamh M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a236325.pdf


Report Date : Jan 1990


Pagination or Media Count : 14


Abstract : Although phagocytes appear to have a redundancy of both oxidative and non-oxidative killing mechanism, nevertheless, bacterial pathogens are still able to evade these defenses in vivo and cause lethal infection. As the mechanisms by which phagocytes function have become detailed at the molecular level, both the recognition of specific bacterial virulence determinants and their effects at specific sites in the phagocyte are also being identified. Knowledge of these interactions may permit the use of immunomodulators either to neutralize theses virulence determinants or to enhance the bactericidal capabilities of the phagocyte.


Descriptors :   *PATHOGENIC MICROORGANISMS , REPRINTS , DEFENSE SYSTEMS , MOLECULAR STATES , BACTERIA , PHAGOCYTES , LETHALITY , INFECTIOUS DISEASES , IN VIVO ANALYSIS , REDUNDANCY , FUNCTIONS , OXIDATION


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE