Accession Number : ADA235425


Title :   Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivo and as Directed by Cloned Cholinesterase DNA Sequences


Descriptive Note : Final rept. 25 Sep 1987-24 Sep 1990


Corporate Author : HEBREW UNIV JERUSALEM (ISRAEL)


Personal Author(s) : Soreq, Hermona


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a235425.pdf


Report Date : 24 Oct 1990


Pagination or Media Count : 156


Abstract : Acetylcholinesterase (ACHE) is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase (BCHE), it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis.


Descriptors :   *CONTROL , BIOLOGY , HUMANS , MOLECULES , HEALTH , ENZYMES , PROTEINS , TARGETS , DEOXYRIBONUCLEIC ACIDS , SEQUENCES , GENES , CLONES , MUSCLES , JUNCTIONS , IN VIVO ANALYSIS , SYNAPSE , AGRICULTURE , ACETYLCHOLINESTERASE , INSECTICIDES , POISONS , CHOLINESTERASE , NERVES , CHEMICAL WARFARE AGENTS , BIOSYNTHESIS , CHOLINERGIC NERVES , ACETYLCHOLINE


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE