Accession Number : ADA233333


Title :   HLA: The Major Histocompatibility Complex of Man


Corporate Author : NAVAL MEDICAL RESEARCH INST BETHESDA MD


Personal Author(s) : Johnson, Armead H ; Hurley, Carolyn K ; Hartzman, Robert J ; Alper, Chester A ; Yunis, Edmond J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a233333.pdf


Report Date : Jan 1991


Pagination or Media Count : 35


Abstract : Survival depends on the immune system's ability to recognize a multitude of foreign substances (antigens) and to respond to them, Although this defense mechanism is basic to survival in a hostile world of microorganisms, this same defense system becomes a major obstacle when attempting to transplant tissues from one individual to another or when malfunction of immune recognition triggers autoaggressive reactions. The major histocompatibility complex (MHC) genes encode proteins that are essential to this immune recognition. Products of the MHC have been grouped into three classes on the basis of structure, genetic origin, and function: Class I, Class II, and Class III. The human Class I molecules include HLA-A, HLA-B, and HLA-C; Class II molecules include HLA-DR, HLA-DQ, and HLA-DP; Class III molecules include the MHC-linked complement components (C2, C4, and BF), 21-hydroxylase (210H), and tumor necrosis factor (TNF).


Descriptors :   *HISTOCOMPATIBILITY , DEFENSE SYSTEMS , FOREIGN , HUMANS , MOLECULES , PROTEINS , NEOPLASMS , SURVIVAL(GENERAL) , RECOGNITION , GENES , IMMUNITY , ANTIGENS , TRANSPLANTATION , NECROSIS , REPRINTS , TISSUES(BIOLOGY)


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE