Accession Number : ADA231185


Title :   Inhalation Toxicology. 11. The Effect of Elevated Temperature on Carbon Monoxide Toxicity


Corporate Author : FEDERAL AVIATION ADMINISTRATION OKLAHOMA CITY OK CIVIL AEROMEDICAL INST


Personal Author(s) : Sanders, Donald C ; Endecott, Boyd R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a231185.pdf


Report Date : Dec 1990


Pagination or Media Count : 18


Abstract : Laboratory rats were exposed (a) to experimental concentrations of carbon monoxide in air at ambient temperature, (b) to elevated temperature atmospheres from 40 deg C to 60 deg C, and (c) to selected carbon monoxide (CO) concentrations at the elevated temperatures in (b). The incapacitating potency of each of the environments was evaluated by measurements of time-to- incapacitation (t sub i) as a function of CO concentration and/or temperature; incapacitation was defined operationally as loss of ability to walk inside a motor-driven, rotating cage enclosed in an exposure chamber. Comparison of data from the combined (CO + elevated temperature) exposures and exposures to CO and elevated temperatures alone indicated than incapacitation occurred earlier when CO inhalation was combined with a whole-body, elevated temperature environment than was observed for the same exposure parameters applied individually. No evidence for a synergistic effect was noted. An empirical equation was derived that allows the calculation of a predicted t sub i for combinations of CO and temperature within the rangers utilized in the experimental exposures.


Descriptors :   *CARBON MONOXIDE , *INHALATION , *TOXICOLOGY , HIGH TEMPERATURE , COMPARISON , EQUATIONS , CHAMBERS , ATMOSPHERES , SYNERGISM , INCAPACITATION , LABORATORY ANIMALS , TOXICITY , PARAMETERS , EXPOSURE(GENERAL) , RATS


Subject Categories : Stress Physiology
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE