Accession Number : ADA230062


Title :   An Experimental Brain Missile Wound: Ascertaining Pathophysiology and Evaluating Treatments to Lower Mortality and Morbidity


Descriptive Note : Annual rept. 14 Apr 1988-13 Apr 1989


Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEW ORLEANS


Personal Author(s) : Carey, Michael E ; Torbati, Dan ; Soblosky, Joweph ; Davidson, June ; Farrell, J B


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a230062.pdf


Report Date : 26 Oct 1990


Pagination or Media Count : 140


Abstract : Chemical regulation of CBF: Normoxic hypocapnia (PaCO to the second power 21 mmHg) significantly reduced total CBF and many rCBFs both before and after wounding but after wounding this response may have been attenuated except around the wound track where CBF reduction was enhanced. Effect of wounding on selected physiologic variables which might account for death. The effect of brain wounding on lung water was insignificant. The effect increased intracranial pressure on brain biogenic amines. The monoaminergic neurotransmitters (EPI, NE, 5-HT) and some their metabolities (DOPAC, HVA, 5-HIAA) were evaluated in selected brain stem areas and the hypothalamus after increases in ICP sufficient to elicit an immediate Cushing response.


Descriptors :   *GUIDED MISSILES , BRAIN , CHEMICALS , WATER , VARIABLES , AMINES , INTERNAL , PRESSURE , LUNG , PHYSIOLOGY , WOUNDS AND INJURIES , DEATH , PATHOPHYSIOLOGY , MORTALITY RATE , NEUROTRANSMITTERS , HYPOTHALAMUS , SKULL , CONTROL


Subject Categories : Anatomy and Physiology
      Weapons Effects(biological)


Distribution Statement : APPROVED FOR PUBLIC RELEASE