Accession Number : ADA228831


Title :   Possible Mechanism for Denervation Effect on Wound Healing


Descriptive Note : Annual rept. 1 May 1989-30 Apr 1990,


Corporate Author : INDIANA UNIV AT BLOOMINGTON


Personal Author(s) : Mescher, Anthony L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a228831.pdf


Report Date : 23 May 1990


Pagination or Media Count : 29


Abstract : This report continued basic research on the role of transferrin, an iron-transport protein required for cell proliferation, in the neural effect on wound healing and tissue regeneration. The system of tissue repair under investigation is the regenerating limb of the axolotl, in which growth is strictly dependent on unknown factors from peripheral nerves. The rationale of the study is to quantify transferrin in segments of ligated normal and regenerating nerves in order to obtain information with which to test the hypothesis that axons transport transferrin to cells of the regenerating tissues. Before experiments of this nature can be undertaken, axolotl transferrin and antibodies against this factor had to be produced so that immunoassays could be developed to measure this protein in nerves, regenerating limbs, and other tissues from axolotls. These goals were accomplished in the earlier phase of the project and during the past year the immunoassay was used to obtain data regarding axonal transport and transferrin. (TTL)


Descriptors :   *HEALING , *WOUNDS AND INJURIES , *PROTEINS , CELLS(BIOLOGY) , PERIPHERAL NERVOUS SYSTEM , NERVES , NERVE TRANSMISSION , NERVE FIBERS , REGENERATION(PHYSIOLOGY) , HYPOTHESES , ANTIBODIES , NERVOUS SYSTEM , IMMUNOASSAY


Subject Categories : Anatomy and Physiology
      Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE