Accession Number : ADA227840


Title :   Pathogenesis of Rift Valley Fever in Rhesus Monkeys: Role of Interferon Response


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Morrill, J C ; Jennings, G B ; Johnson, A J ; Cosgriff, T M ; Gibbs, P H


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a227840.pdf


Report Date : Jan 1990


Pagination or Media Count : 18


Abstract : Rhesus monkeys inoculated intravenously with Rift Valley fever (RVF) virus presented clinical disease syndromes similar to human cases of RVF. All 17 infected monkeys had high-titered viremias but disease ranged from clinically inapparent to death. Three (18%) RVF virus-infected monkeys developed signs of hemorrhagic fever characterized by epistaxis, petechial to purpuric cutaneous lesions, anorexia, and vomiting prior to death. The 14 remaining monkeys survived RVF viral infection but, 7 showed clinical signs of illness characterized by diminished food intake, cutaneous petechiae, and occasional vomiting. The other 7 monkeys showed no evidence of clinical disease. All monkeys had detectable serum interferon 2-30 h after infection, but 4 of 7 monkeys that did not develop clinical illness had serum interferon titers within 12h after infection. In lethally infected macques, indices of hepatic function and blood coagulation were abnormal within 2 days, implicating early pathogenetic events as critical determinants of survival.


Descriptors :   *DISEASES , *CLINICAL MEDICINE , HUMANS , SIGNS AND SYMPTOMS , RESPONSE , ILLNESS , INDEXES , LIVER , INTERFERON , INFECTIOUS DISEASES , HEMORRHAGIC FEVERS , RIFT VALLEY FEVER , VIRUS DISEASES , DEATH , PATHOGENESIS , LESIONS , RHESUS MONKEYS , FOOD CONSUMPTION , MONKEYS , ANOREXIA , SKIN DISEASES , BLOOD COAGULATION , FUNCTIONS , REPRINTS


Subject Categories : Medicine and Medical Research


Distribution Statement : APPROVED FOR PUBLIC RELEASE