Accession Number : ADA225315


Title :   New Electrorelease Systems Based on Microporous Membranes


Descriptive Note : Technical rept.


Corporate Author : COLORADO STATE UNIV FORT COLLINS DEPT OF CHEMISTRY


Personal Author(s) : Tierney, Michael J ; Martin, Charles R


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a225315.pdf


Report Date : 02 Aug 1990


Pagination or Media Count : 28


Abstract : Electrorelease systems have previously been based on electrochemical release of molecules chemically entrapped in polymer membranes. A new type of electrorelease system is described; this system is based on a microporous Al sub 2 0 sub 3 membrane covered with a barrier layer which seals the pores. Electrorelease occurs upon electrochemical dissolution or disruption of the barrier layer, which opens the pores. Two different barrier layers are investigated: silver and Na(+)-form Nafion. The electrorelease rate can be controlled by partially removing the barrier layer or by dividing the barrier layer into several individually-addressable zones. This configuration may also be used as a multi-dose device. Keywords: Drug release, Insulin release.


Descriptors :   *RELEASE , *MEMBRANES , *ELECTROCHEMISTRY , SILVER , BARRIERS , INSULIN , POROUS MATERIALS , DRUGS , POLYMERS , MOLECULES , LAYERS


Subject Categories : Physical Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE