Accession Number : ADA224478


Title :   Antibody Responses in the Nonhuman Primate, Macaca Fascicularis, to Protein Toxins


Descriptive Note : Master's thesis


Corporate Author : TEXAS UNIV AT SAN ANTONIO


Personal Author(s) : Bauman, Geoffrey


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a224478.pdf


Report Date : May 1990


Pagination or Media Count : 135


Abstract : Bacterial associated protein toxins have been implicated in the pathologic processes in several diseases of man and animals. The bacterium Actinobacillus actinomycetemcomitans produces a protein toxin, leukotoxin, which has been defined by recent research as the primary pathologic factor associated with certain destructive periodontal diseases. Definition of the immunologic relationship between host and protein toxins may serve to identify critical factors in the scheme which might be manipulated for control of the destructive process. The long-range goal of research in this arena is to better understand the immune response to antigenic challenge with protein toxins in man. However, for ethical reasons, some immunopathologic factors cannot be manipulated for appropriate study in man. The nonhuman primate (NhP) has, in previous investigations, been shown to be more closely immunologically related to man than any othr animal model.


Descriptors :   *ACTINOBACILLUS , *IMMUNOLOGY , BACTERIA , PROTEINS , DESTRUCTION , DISEASES , LONG RANGE(TIME) , ANTIBODIES , ANIMALS , PATHOLOGY , RESPONSE(BIOLOGY) , RESEARCH MANAGEMENT , IMMUNITY , TOXINS AND ANTITOXINS , DENTISTRY , MACACA FASCICULARIS , MODELS , HUMANS


Subject Categories : Biochemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE