Accession Number : ADA215151


Title :   Dermal Sensitization Potential of DIGL-RP Solid Propellant in Guinea Pigs


Descriptive Note : Rept. for 4 Apr-6 May 1986


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : LeTellier, Yvonne C ; Brown, Larry D ; Korte, Jr, Don W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a215151.pdf


Report Date : Oct 1989


Pagination or Media Count : 44


Abstract : The Department of Defense is considering the use of diethyleneglycol dinitrate (DEGDN) as a replacement for nitroglycerin in new propellant formulations. DIGL-RP Solid Propellant was evaluated for its potential to produce dermal sensitization in male guinea pigs. The Buehler test, which utilizes repeated closed patch inductions with the test compound, was used for this evaluation. No evidence that DIGL-RP Solid Propellant induced sensitization was obtained in the study. Keywords: Mammalian toxicology, Buehler test, Munition.


Descriptors :   *SKIN(ANATOMY) , *ETHYLENE GLYCOL , *NITRATES , *SOLID PROPELLANTS , *TOXICITY , MALES , NITROGLYCERIN , TOXICOLOGY , FORMULATIONS(CHEMISTRY) , TEST AND EVALUATION , GUINEA PIGS , MAMMALS , DEPARTMENT OF DEFENSE , SENSITIVITY


Subject Categories : Toxicology
      Ammunition and Explosives


Distribution Statement : APPROVED FOR PUBLIC RELEASE