Accession Number : ADA215070


Title :   A Literature Review on the Mechanism of Action of Sulphur and Nitrogen Mustard


Descriptive Note : Technical rept.


Corporate Author : MATERIALS RESEARCH LABS ASCOT VALE (AUSTRALIA)


Personal Author(s) : Gray, Peter J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a215070.pdf


Report Date : Jul 1989


Pagination or Media Count : 46


Abstract : The literature describing the mechanism of action of sulphur and nitrogen mustard is reviewed. The conclusion drawn is that the available evidence suggests that DNA is the most important molecular target of these compounds. However, the final outcome of poisoning is modulated by other factors such as DNA repair, glutathione levels and drug transport.


Descriptors :   *POISONING , *MUSTARD AGENTS , LITERATURE SURVEYS , MOLECULES , TARGETS , DEOXYRIBONUCLEIC ACIDS , TRANSPORT PROPERTIES , REPAIR , AUSTRALIA , NITROGEN MUSTARDS , GLUTATHIONE


Subject Categories : Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE