Accession Number : ADA215044


Title :   A Multidisciplinary Study of Ciguatoxin and Related Low Molecular Weight Toxins from Marine Sources


Descriptive Note : Final rept. 15 Aug 1985-30 Jun 1987,


Corporate Author : HAWAII UNIV AT MANOA HONOLULU DEPT OF PHARMACOLOGY


Personal Author(s) : Bailey, Leslie E ; Hokama, Yoshitsugi ; Miyahara, James T ; Scheuer, Paul J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a215044.pdf


Report Date : Aug 1989


Pagination or Media Count : 52


Abstract : The work in this report deals with the isolation and purification of ciguatoxin from ciguateric fish, the pharmacology and toxicology of ciguatoxin and other toxins extracted from various assays and progress made on a system for detection of ciguateric fish flesh. Ciguatoxin has been isolated from livers and viscera of eels obtained from Pacific Islands where ciguatera is endemic. Evaluation of the pharmacology and toxicology has been both in vitro and in vivo systems but has been hampered by a shortage of purified toxins. The immunological stick method of assaying for ciguatera in fish has yielded interesting and promising results. Work on all of these aspects of ciguatera toxicity and toxicity to other marine toxins is proceeding at an accelerated pace. (jes)


Descriptors :   *TOXICOLOGY , EELS , TOXICITY , MOLECULAR WEIGHT , ISOLATION , IN VITRO ANALYSIS , PURIFICATION , LIGHTWEIGHT , LIVER , IN VIVO ANALYSIS , SHORTAGES , ASSAYING , TOXINS AND ANTITOXINS , FISHES , PHARMACOLOGY , ORGANS(ANATOMY) , PACIFIC OCEAN ISLANDS , SOURCES , DETECTION


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE