Accession Number : ADA213881


Title :   Relationship Between Organophosphate Toxicity and Choline Metabolism


Descriptive Note : Final rept. 15 Nov 1982-15 Dec 1985


Corporate Author : LOUISIANA STATE UNIV MEDICAL CENTER NEWORLEANS


Personal Author(s) : Wecker, Lynn


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a213881.pdf


Report Date : 06 Jun 1986


Pagination or Media Count : 68


Abstract : Although research on the organophosphate cholinesterase (Ch/E) inhibitors has focused primarily on inhibition of acetylcholinesterase (AChE) and enhanced cholinergic transmission, these actions alone cannot explain the biochemical and physiological effects that persist long after enzyme activity has returned to normal. Although evidence indicates that some organophosphates alter the disposition and metabolism of choline and choline-containing compounds in the nervous system, the relationship of these changes to the toxicological manifestations of ChE inhibition has not been investigated. Organophosphate cholinesterase inhibitors; Brain; Choline; Acetylcholine; Lipids; Phospholipids; Acetylcholinesterase; Convulsions; Phospholipases; Chemical warfare agents.


Descriptors :   *TOXICITY , *CHOLINES , *METABOLISM , *CHEMICAL WARFARE AGENTS , *ORGANOPHOSPHATES , BRAIN , BIOCHEMISTRY , ENZYMES , LIPIDS , TRANSMITTANCE , PHYSIOLOGICAL EFFECTS , NERVOUS SYSTEM , INHIBITION , ACETYLCHOLINESTERASE , CHOLINESTERASE INHIBITORS , CHOLINESTERASE , CHOLINERGIC NERVES , ACETYLCHOLINE , PHOSPHOLIPIDS , CONVULSIVE DISORDERS


Subject Categories : Biochemistry
      Chemical, Biological and Radiological Warfare


Distribution Statement : APPROVED FOR PUBLIC RELEASE