Accession Number : ADA212776


Title :   Combined Atropine and 2-PAM Cl Effects on Tracking Performance and Visual, Physiological, and Psychological Functions


Descriptive Note : Final rept. 1 Sep 1983-31 May 1986


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : Penetar, David M ; Haegerstrom-Portnoy, Gunilla ; Jones, Reese T


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a212776.pdf


Report Date : Dec 1988


Pagination or Media Count : 9


Abstract : Combinations of atropine (up to 4 mg/70 kg) and 2-PAM CL (up to 1200 mg/70 kg) were studied for their effects on a pursuit tracking task six visual functions, heart rate and blood pressure, and cognitive functions as measured by six psychological tests. Tracking performance in both bright and dim light was significantly degraded up to 3.5 hr after injection. High- and low-contrast near acuity was significantly altered up to 6 hr after injection, whereas accommodation and pupil size remained altered for 24 hr. Elevated pulse rates were observed for 4 hr. Elevated systolic blood pressures were observed for 2 hr while diastolic pressures remained elevated for 6 hr. No drug effects were found for the psychological tests. Overall, the observed effects of these two drugs in combination are qualitatively similar to those of atropine alone although they are of greater magnitude. On two measures (accommodation and diastolic blood pressure) 2, PAM CL was found to significantly potentiate the atropine effect. Keywords: Pralidoxime, antidotes; Antidotes; Psychological effects. Reprints.


Descriptors :   *PHYSIOLOGICAL EFFECTS , *ANTIDOTES , *RESPONSE(BIOLOGY) , *ATROPINE , FUNCTIONS , REPRINTS , CONTRAST , SIZES(DIMENSIONS) , EYE , PURSUIT COURSES , LOW INTENSITY , BLOOD PRESSURE , HEART RATE , PSYCHOLOGY , DRUGS , PSYCHOLOGICAL TESTS , COGNITION , ACUITY , TRACKING , OPTICAL IMAGES , PULSE RATE


Subject Categories : Psychology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE