Accession Number : ADA210295


Title :   Development of Elastomeric Polypeptide Biomaterials


Descriptive Note : Annual rept. 1 Jun 1988-31 May 1989


Corporate Author : ALABAMA UNIV IN BIRMINGHAM LAB OF MOLECULAR BIOPHYSICS


Personal Author(s) : Urry, Dan W ; Prasad, K U ; Morrow, Casey


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a210295.pdf


Report Date : 01 Jul 1989


Pagination or Media Count : 115


Abstract : The purpose of this research was to design, prepare and characterize novel elastomeric polymers comprised of repeating peptide sequences, primarily the elastin pentamer and analogs of it alone and combined with repeating related hexapeptides and/or tetrapeptides. The purpose is to develop polymers with different elastic moduli and increased extension limits, polymers with different temperature ranges for their inverse temperature transitions over which elastomeric force dramatically changes, polymers in which different intensities and frequencies of their dielectric relaxations and polymers with wider temperature ranges over which they function as nearly ideal elastomers. In the elastomer design, the dominant repeat units will be pentamers and tetramers. Hexamers and alanine-rich, lysine-containing cross-linking sequences will be used to fine-tune properties. Keywords; Polymer chemistry; Biomaterials.


Descriptors :   *POLYMERS , *PEPTIDES , *ELASTOMERS , SEQUENCES , ALBUMINOIDS , CROSSLINKING(CHEMISTRY) , LIMITATIONS , RELAXATION , INVERSION , TRANSITIONS , RANGE(EXTREMES) , DIELECTRICS , MODULUS OF ELASTICITY , TEMPERATURE , CHEMISTRY


Subject Categories : Biochemistry
      Polymer Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE