Accession Number : ADA208927


Title :   Biomedical Studies with the Free Electron Laser


Descriptive Note : Final rept. 1 Feb 86-31 Jan 88


Corporate Author : BECKMAN LASER INST AND MEDICAL CLINIC IRVINE CA


Personal Author(s) : Berns, Michael W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a208927.pdf


Report Date : 15 May 1989


Pagination or Media Count : 219


Abstract : An electrostatic VandeGraff FEL was used to study the effects of infrared radiation on the synthesis of DNA and RNA in living vertebrate cells in culture. The laser was operated at wavelengths of 165 and 200 microns at power densities of 0.1 - 30 KW/sq.cm. Cells were incubated in radioactive precursors to either DNA or RNA following exposure to the FEL and analyzed by light microscope autoradiography. The results indicated that the 200 micron wavelength inhibited DNA but not RNA synthesis in a subpopulation of cells and the 165 micron wavelength inhibited RNA synthesis and not DNA synthesis. The statistical significance for the 200 micron wavelength studies was p = 0.05 and for the 165 micron wavelength studies p = 0.001 - 0.005. Partial Contents: Delayed Retinal Effects of Frequency Doubled YAG Laser (532 nm); Tumor Destruction in Photodynamic Therapy; Comparison of Continuous Wave Lasers for Endarterectomy of Experimental Atheromas; Mechanism of Tumor Destruction Following Photodynamic Therapy with Hematoporphyrin Derivative, Chlorin, and Phthalocyanine; Phycocyanin; Laser Activation, Cytotoxic Effects, and Uptake in Human Atherosclerotic Plague; Basic Laser Physics and Tissue Interaction; Biological Studies on the Free Electron Laser; Ablation of Bone and Methacrylate by a Prototype Mid-Infrared Erbium; YAG Laser; and Corneal Healing after Excimer Laser Surface Ablation.


Descriptors :   *INFRARED RADIATION , *RADIATION EFFECTS , YAG LASERS , ABLATION , DENSITY , ACTIVATION , BIOLOGY , HUMANS , SYNTHESIS , CELLS , PRECURSORS , DESTRUCTION , LIGHT , NEOPLASMS , PROTOTYPES , LASERS , DEOXYRIBONUCLEIC ACIDS , FREE ELECTRON LASERS , PHTHALOCYANINES , VERTEBRATES , RADIOACTIVITY , THERAPY , POWER , LIFE(BIOLOGY) , MICROSCOPES , CELLS(BIOLOGY) , EXCIMERS , RIBONUCLEIC ACIDS , BIOSYNTHESIS , BIOMEDICINE , INTERMEDIATE INFRARED RADIATION , ERBIUM , HEALING , CONTINUOUS WAVE LASERS , BONES , ATHEROSCLEROSIS , AUTORADIOGRAPHY , PLAGUES , CORNEA


Subject Categories : Radiobiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE