Accession Number : ADA208537


Title :   On the Toxicity and Metabolism of the Trichothecene Mycotoxin T-2 Toxin,


Corporate Author : NORWEGIAN DEFENCE RESEARCH ESTABLISHMENT KJELLER


Personal Author(s) : Johnsen, Helge


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a208537.pdf


Report Date : 20 Jun 1988


Pagination or Media Count : 57


Abstract : The present study deals with toxicological effects and metabolism of the trichothecene mycotoxin T-2 toxin. T-2 toxin was shown to cause a marked decrease in cell production of bone marrow 24 hours after T-2 toxin administration. Furthermore, necrotic injuries in skeletal muscle, heart and probably in the intestine were indicated by an increase in clinically relevant enzymes. The activity of coagulation, fibrinolysis and kallikrein-kinin system was severely depressed after a sublethal dose of T-2 toxin. The maximal effects on the plasma proteases as well as the necrotic injuries were observed 24 hours after administration, corresponding to the time the animals usually die when receiving a lethal dose. The effect of T-2 toxin on plasma protease enzymes involved in these systems was suggested to be secondary to cytotoxic effects on the vascular endothelium. T-2 toxin was rapidly hydrolysed and detoxified by rat liver microsomal fraction into HT-2 toxin as the main metabolite. The enzyme responsible for the hydrolysis of T-2 to HT-2 toxin was identified as a carboxylesterase. Keywords: Trichothecenes; Mycotoxins. (AW)


Descriptors :   *METABOLISM , *TOXICITY , *PHYTOTOXINS , CELLS(BIOLOGY) , COAGULATION , CYTOTOXINS , DOSAGE , ENDOTHELIUM , ENZYMES , FIBRINOLYSIS , FUNGI , HYDROLYSIS , INTESTINES , LETHAL DOSAGE , METABOLITES , PEPTIDE HYDROLASES , PRODUCTION , SECONDARY , SUBLETHAL DOSAGE , TOXICOLOGY , FUSARIUM


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE