Accession Number : ADA206405


Title :   Molecular Cloning of Human Gene(s) Directing the Synthesis of Nervous System Cholinesterases


Descriptive Note : Annual rept. no. 4, Nov 1985-Aug 1987, Final rept. Nov 1984-Aug 1987


Corporate Author : WEIZMANN INST OF SCIENCE REHOVOT (ISRAEL)


Personal Author(s) : Hermona, Soreq


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a206405.pdf


Report Date : Sep 1987


Pagination or Media Count : 71


Abstract : Cholinesterases (ChEs) are highly polymorphic serine hydrolases involved in the termination of neurotransmission in cholinergic synapses and neuromuscular junctions. Both the levels and the molecular forms of ChEs were shown to be modulated during development, denervation and regeneration processes in various species. In order to examine the molecular mechanisms underlying these phenomena in humans, we have used oligodeoxynucleotide probes to isolate full-length cDNA clones coding for human ChE. These clones are currently employed in our laboratory to study the biogenesis of human ChE at various levels of gene expression. Keywords: Cholinesterase; Chromosomal mapping; cDNA hybridization; Genomic clones; Xenopus oocytes microinjection.


Descriptors :   *CLONES , *CHOLINESTERASE , *GENES , CODING , NERVOUS SYSTEM , LABORATORIES , MAPPING , MUSCLES , GENETIC ENGINEERING , JUNCTIONS , SYNAPSE , MOLECULAR PROPERTIES , NERVES , BIOSYNTHESIS , POLYMORPHISM , CHOLINERGIC NERVES , SERINE , HYDROLASES , HYBRIDIZATION , CHROMOSOMES , REGENERATION(PHYSIOLOGY) , HUMANS , MOLECULES


Subject Categories : Biochemistry
      Genetic Engineering and Molecular Biology


Distribution Statement : APPROVED FOR PUBLIC RELEASE