Accession Number : ADA201959


Title :   Dermal Sensitization Potential of Diethyleneglycol Dinitrate (DEGDN) in Guinea Pigs


Descriptive Note : Rept. for 7 Mar-15 Apr 1985


Corporate Author : LETTERMAN ARMY INST OF RESEARCH PRESIDIO OF SAN FRANCISCO CA


Personal Author(s) : Hiatt, Gerald F ; Ryabik, John R ; Korte, Jr, Don W


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a201959.pdf


Report Date : Oct 1988


Pagination or Media Count : 37


Abstract : The Department of Defense is considering the use of either diethyleneglycol dinitrate (DEGDN), triethyleneglycol dinitrate (TEGDN), or trimethylolethane trinitrate (TMETN) as a replacement for nitroglycerin in new propellant formulations. However, considerable gaps in the toxicology data of the compounds were identified during a review of their health effects (1) conducted for the US Army Biomedical Research and Development Laboratory (USABRDL). Consequently, USABRDL has tasked the Division of Toxicology, Letterman Army Institute of Research (LAIR), to conduct an initial health effects evaluation of the proposed replacement nitrate esters. Keywords: Dermal sensitization, Diethyleneglycol dinitrate, DEGDN, Buehler test, Guinea pigs.


Descriptors :   *ETHYLENE GLYCOL , *TOXICOLOGY , ARMY RESEARCH , METHYL RADICALS , HEALTH , PROPELLANTS , ETHYLENE , REPLACEMENT , LABORATORIES , MEDICAL RESEARCH , ESTERS , ETHANES , BIOMEDICINE , HYDROXYL RADICALS , FORMULATIONS(CHEMISTRY) , NITRATES , GUINEA PIGS , GLYCOLS , NITROGLYCERIN , TEST AND EVALUATION , DEPARTMENT OF DEFENSE


Subject Categories : Toxicology
      Ammunition and Explosives


Distribution Statement : APPROVED FOR PUBLIC RELEASE