Accession Number : ADA201152


Title :   Enterotoxins of Staphylococci


Corporate Author : ARMY MEDICAL RESEARCH INST OF INFECTIOUS DISEASES FORT DETRICK MD


Personal Author(s) : Spero, Leonard ; Johnson-Winegar, Anna ; Schmidt, James J


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a201152.pdf


Report Date : Jan 1988


Pagination or Media Count : 34


Abstract : Over the last 15 years, significant accomplishments have been made in several aspects of staphylococcal enterotoxin research; for example, all of the known serotypes have been purified, SEC 1 has been chemically sequenced, the genes of both SEA and SEB have been cloned and their DNA sequenced, and the roles of plasmids and phage have been developed. However, major gaps in our knowledge remain. Foremost among these are the mode of action, the nature of the active site, and the three-dimensional structure of the molecules. Establishing the amino acid sequence of type E should not pose a great problem and, with the soon-to-be-published SEA sequence, a definition of the conserved residues in four serotypes will be of enormous value. The crystals of SEB recently obtained provide reason to hope for a successful x-ray diffraction study. The most urgent need is for a cell system with which the enterotoxins bind and/or induce a well-defined biochemical effect. It is to be hoped that the effect on cutaneous mast cells will provide a step in this direction. Keywords: Epidemiology, Clones, Genetics, Immunology, Reprints.


Descriptors :   *MOLECULAR STRUCTURE , *ENTEROTOXINS , *STAPHYLOCOCCUS , *IMMUNOLOGY , CRYSTALS , DEOXYRIBONUCLEIC ACIDS , CHROMOSOMES , SEQUENCES , THREE DIMENSIONAL , MAST CELLS , GENES , CLONES , CELLS(BIOLOGY) , SEROLOGY , GENETICS , ANTIGENS , EPIDEMIOLOGY , AMINO ACIDS , BACTERIAL TOXINS , SKIN DISEASES , X RAY DIFFRACTION , SITES , BACTERIOPHAGES , MOLECULES , BIOCHEMISTRY


Subject Categories : Genetic Engineering and Molecular Biology
      Medicine and Medical Research
      Toxicology
      Microbiology


Distribution Statement : APPROVED FOR PUBLIC RELEASE