Accession Number : ADA198722


Title :   Proceedings of the International Symposium on Subtypes of Muscarinic Receptors 2 (2nd) Held in Boston, Massachusetts on August 22-24 1985


Descriptive Note : Final rept. 22 Aug 1985-30 Apr 1986


Corporate Author : BOSTON UNIV MA SCHOOL OF MEDICINE


Personal Author(s) : Levine, Ruth R ; Birdsall, Nigel J ; Giachetti, Antonio ; Hammer, Rudolf ; Iversen, Leslie L ; Jenden, Donald J ; North, R A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a198722.pdf


Report Date : 30 Apr 1986


Pagination or Media Count : 123


Abstract : Partial contents: The molecular basis of receptor selectivity; Biochemical studies on muscarinic receptors in porcine atrium; Muscarinic receptor subclasses: The binding properties of the soluble receptor binding sites; Characteristics of two biochemical responses to stimulation of muscarinic cholinergic receptors; Muscarinic receptors and membrane ion conductances; Muscarinic receptors in the submucous plexus and their roles in mucosal ion transport; A mechanism of muscarinic excitation in dissociated smooth muscle cells; In-vivo labelling of peripheral muscarinic receptors; Modulation of muscarinic receptors and their interactions; The cholinergic hypothesis of dementia; Biochemical and functional basis of putative muscarinic receptor subtypes and its implications; Mapping of subtypes of muscarinic receptors in the human brain with receptor autoradiographic techniques; Inositol lipids and signal transduction at CNS muscarinic receptors; Mechanisms of muscarinic excitatory synaptic transmission in ganglia and brain; Pirenzepine discriminates among ionic responses to acetylcholine in guinea-pig cerebral cortex and reticular nucleus of thalamus. Keywords: Pharmacological antagonists, Binding sites, Alzheimers disease, Drugs, Pharmacological agonists.


Descriptors :   *NERVES , *NERVE TRANSMISSION , SYMPOSIA , BRAIN , HUMANS , BIOCHEMISTRY , NERVOUS SYSTEM DISEASES , SIGNALS , MUSCLES , RECEPTION , RESPONSE(BIOLOGY) , DRUGS , SOLUBILITY , MODULATION , CELLS(BIOLOGY) , SYNAPSE , HEART , CENTRAL NERVOUS SYSTEM , SENSE ORGANS , ION EXCHANGE , PHARMACOLOGICAL ANTAGONISTS , CHOLINERGIC NERVES , MUCOUS MEMBRANES , IONIC CURRENT , SWINE , AUTORADIOGRAPHY , MUSCARINE , GANGLIA , NEUROCHEMICAL TRANSMISSION , MEMBRANES(BIOLOGY) , STIMULATION(PHYSIOLOGY)


Subject Categories : Biochemistry
      Anatomy and Physiology
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE