Accession Number : ADA195915


Title :   Infectious Multiple Drug Resistance in the Enterobacteriaceae


Descriptive Note : Annual rept. 1 Jan-30 Sep 1983


Corporate Author : STANFORD UNIV CA


Personal Author(s) : Falkow, Stanley


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a195915.pdf


Report Date : 01 Oct 1983


Pagination or Media Count : 21


Abstract : A new quantitative assay for the determination of E. coli heat-stable enterotoxin has been developed which is about 10-fold more sensitive than existing methods. A strategy for the development of subunit vaccines has been tested using specific peptides of the binding region of cholera toxin. Although there have been numerous reports of the relationship between E. coli LT toxin (and cholera toxin) and a putative enterotoxin of Salmonella typhimurium, we have been unable to demonstrate any DNA sequence homology between known sequences of E. coli LT, ST or cholera toxin with the nucleic acid of Salmonella.


Descriptors :   *ENTEROTOXINS , *DRUGS , *RESISTANCE(BIOLOGY) , *ENTEROBACTERIACEAE , PEPTIDES , REPORTS , THERMAL STABILITY , REGIONS , SEQUENCES , ESCHERICHIA COLI , INFECTIOUS DISEASES , DETERMINATION , ASSAYING , SALMONELLA , TOXINS AND ANTITOXINS , CHOLERA , VACCINES , BACTERIAL TOXINS , NUCLEIC ACIDS , SALMONELLA TYPHIMURIUM


Subject Categories : Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE