Accession Number : ADA189504


Title :   Studies to Control Endemic Typhoid Fever in Chile


Descriptive Note : Final rept. 1 Sep 1981-14 Dec 1986


Corporate Author : MARYLAND UNIV BALTIMORE CENTER FOR VACCINE DEVELOPMENT


Personal Author(s) : Levine, Myron M ; Ferreccio, Catterine


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a189504.pdf


Report Date : 30 Mar 1987


Pagination or Media Count : 188


Abstract : A multi-faceted program of applied research has been undertaken in collaboration with the Ministry of Health of Chile intended to lead to control of endemic typhoid fever in Santiago, Chile. These studies include: 1) Maintenance of prospective field trials evaluating the efficacy of Ty21a live oral typhoid vaccine given in various formulations and immunization schedules. 2) The first evaluations of Ty21a vaccine in infants and pre-school children. 3) Development of a new enzyme-linked immunosorbent assay (ELISA) to measure Vi antibodies and its use as a serologic screening test to identify chronic typhoid carriers. 4) Evaluation of a new oral antibiotic regimen to eradicate the chronic typhoid carrier state without resort to surgery. Keywords: Salmonellosis; Vaccine; Epidemiology; Enteric infections.


Descriptors :   *IMMUNOASSAY , *EPIDEMIOLOGY , *SERODIAGNOSIS , *VACCINES , *ANTIBIOTICS , *TYPHOID , TEST AND EVALUATION , ENZYMES , FIELD TESTS , EFFICIENCY , INFANTS , CHILE , SALMONELLOSIS , IMMUNIZATION , FEVERS , GASTROINTESTINAL DISEASES , SEROLOGY , ANTIBODIES , INFECTIOUS DISEASES , SURGERY


Subject Categories : Medicine and Medical Research
      Pharmacology


Distribution Statement : APPROVED FOR PUBLIC RELEASE