Accession Number : ADA189254


Title :   Research and Development on Inhalation Toxicologic Evaluation of Red Phosphorus/Butyl Rubber Combustion Products. Phase 4


Descriptive Note : Final rept. Jul 1984-May 1986


Corporate Author : IIT RESEARCH INST CHICAGO IL LIFE SCIENCES RESEARCH DIV


Personal Author(s) : Aranyi, Catherine


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a189254.pdf


Report Date : 15 Nov 1986


Pagination or Media Count : 333


Abstract : The no-measurable effect level of inhaled smoke of red phosphorus/ butyl rubber (RP/BR) combustion products in male Sprague Dawley rats was evaluated in two subchronic studies. The rats were exposed for 13 weeks to filtered air to RP/BR aerosol in the second study. Biological endpoints examined within 24 hr of the last exposure and for selected exposure groups following an 8-week recovery period included clinical signs, body weights, pulmonary bactericidal activity and histopathology of the lungs for both studies, with pulmonary cellular responses, neurobehavioral activity and histopathology of all major organs also examined in the first (higher exposure concentration) study. During the first study 10.8% of the rats exposed to 1.20 mg/L died spontaneously or were necropsied in a moribund state. Statistically significant decreases in body weights and body weight gains were observed. A significant decrease in food consumption was only seen after four weeks of exposure. Positive antibody titers to PVM were found but no lesions characteristic of this infection were found and no deaths were due to PVM. Neurobehavioral activity parameters were not affected. Histologically no exposure-related changes were found in tissues outside of the respiratory tract. An in vitro genetic toxicology study demonstrated that this material does not cause point mutations of bacteria, primary DNA damage in rat hepatocytes, or clastogenic damage in Chinese Hamster Ovary cells under the conditions tested. Keywords: Fibrosis, Inhalation toxicology, Exposure(physiology), Alveolar macrophages, Phosphoric acid, Radiolabeled bacteria, Terminal bronchiolar fibrosis.


Descriptors :   *PHOSPHORUS , *COMBUSTION PRODUCTS , *TOXIC TOLERANCES , *BUTYL RUBBER , TEST AND EVALUATION , AEROSOLS , DAMAGE , RATS , BACTERIA , RED(COLOR) , SIGNS AND SYMPTOMS , DEOXYRIBONUCLEIC ACIDS , MUTATIONS , SMOKE , PHYSIOLOGICAL EFFECTS , LUNG , RESPIRATORY SYSTEM , ANTIBODIES , RESPONSE(BIOLOGY) , LIVER , INFECTIOUS DISEASES , OVARIES , FIBROSIS , GERMICIDES , INHALATION , FOOD CONSUMPTION , PHOSPHORIC ACIDS , ORGANS(ANATOMY) , TOXICOLOGY , LESIONS , HISTOPATHOLOGY , RADIOACTIVE ISOTOPES , LABELED SUBSTANCES , HAMSTERS , BODY WEIGHT , CELLS(BIOLOGY)


Subject Categories : Toxicology
      Pyrotechnics


Distribution Statement : APPROVED FOR PUBLIC RELEASE