Accession Number : ADA183116


Title :   Toxic Hazards Research Unit Annual Report: 1986


Descriptive Note : Rept. no. 23, Jan-Oct 1986


Corporate Author : NORTHROP SERVICES INC - ENVIRONMENTAL SCIENCES DAYTON OH


Personal Author(s) : Houston, William E ; Kutzman, Raymond S ; Carpenter, Robert L


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a183116.pdf


Report Date : Apr 1987


Pagination or Media Count : 194


Abstract : Investigations were conducted on the dermal an ocular toxicity of surfactants and hydraulic fluids of interest to the United States military. Candidate materials, under consideration for novel new uses and for replacement of currently used materials have been investigated for toxicological characterization. These materials have included hydraulic fluids, lubricating oils, clothing materials, organometallic complexes, and decontamination agents. Continued interest by the military in the toxicological characteristics of fuels has been addressed with studies designed to establish analytical methods for measuring methylhydrazine concentration in blood, the conduct of dermal exposures of rats to hydrazine, investigation of the teratogenic potential of Otto Fuel II, and the development of cell culture methods for comparison of liver and kidney cell metabolism of trimethylpentane. A new research effort to develop computer-based pharmacodynamic models has been initiated. Investigations of the toxicity of chemicals of interest to the Air Force Installation Restoration Program have been initiated. The toxicity of selected materials associated with chemical defense programs has been addressed including: the evaluation of selected chemicals associated with the production of binary agents under development by the US Army: investigation of the toxicity of materials which show potential as simulant agents to be used in training exercises; and pharmacokinetic modeling of the toxicity of organophosphate chemicals.


Descriptors :   *DECONTAMINATION , *CELLS , *SURFACE ACTIVE SUBSTANCES , *TOXICOLOGY , *EXPOSURE(PHYSIOLOGY) , COMPUTERIZED SIMULATION , DEFENSE SYSTEMS , TOXIC HAZARDS , RATS , TOXICITY , FUELS , PHARMACOLOGY , ORGANOPHOSPHATES , BLOOD , CULTURES(BIOLOGY) , SKIN(ANATOMY) , CELLS(BIOLOGY) , CLOTHING , LIVER , PHARMACOKINETICS , BINARY CHEMICAL AGENTS , LUBRICATING OILS , KIDNEYS , CHEMICAL WARFARE , ORGANOMETALLIC COMPOUNDS , MATERIALS , CHEMICALS , MODELS , HYDRAZINES , PRODUCTION


Subject Categories : Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE