Accession Number : ADA179811


Title :   Molecular Basis of Paraltyic Neurotoxin Action on Voltage-Sensitive Sodium Channels


Descriptive Note : Annual summary rept. 15 Sep 1984-14 Sep 1985


Corporate Author : WASHINGTON UNIV SEATTLE DEPT OF PHARMACOLOGY


Personal Author(s) : Catterall, William A


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a179811.pdf


Report Date : 14 Oct 1985


Pagination or Media Count : 27


Abstract : In year 1 of this project, progress was made on several objectives: A) The sites and mechanisms of action on the sodium channel were examined and further defined for three new classes of neurotoxins: Goniopora toxins, Brevetoxins, and Conotoxins; B) Monoclonal antibodies with high affinity for the mammalian neuronal sodium channel were developed and methods to screen them for activity at neurotoxin binding sites were established; and C) Site-directed antibodies against defined regions of the amino acid sequence of the sodium channel were prepared and shown to bind at discrete negatively charged subsites on the extracellular surface of the channel that may form part of neurotoxin receptor sites. Keywords: Ion transport, Action potentials, Electrical excitability.


Descriptors :   *SODIUM , *CHANNELS , *TOXINS AND ANTITOXINS , *PARALYSIS , MAMMALS , SITES , SEQUENCES , SURFACES , NERVOUS SYSTEM , NERVE CELLS , ANTIBODIES , CLONES , BINDERS , SENSE ORGANS , AMINO ACIDS , ION EXCHANGE , CNS DEPRESSANTS


Subject Categories : Biochemistry
      Toxicology


Distribution Statement : APPROVED FOR PUBLIC RELEASE