Accession Number : ADA179197
Title : Regulation of Neurotransmitter Responses in the Central Nervous System.
Descriptive Note : Final rept. 11 May 85-31 Jul 86,
Corporate Author : TEXAS UNIV MEDICAL SCHOOL AT HOUSTON
Personal Author(s) : Enna,Salvatore J
Report Date : 01 May 1987
Pagination or Media Count : 103
Abstract : The aim of this study was to characterize the mechanism whereby activation of gamma-aminobutyric acid(B) (GABA(B)) receptors augments (modulates) receptor-mediated second and alpha-adrenergic agonists to augment the cyclic AMP response to isoproterenol was greatly diminished in the presence of EGTA or quinacrine. Likewise, this response was attenuated in the brains of animals treated chronically with corticosterone. Moreover, it was discovered that phorbol esters augment the second messenger response in a manner similar to the GABA(B) and alpha-adrenergic agonists. Phosphorylation studies revealed that exposure of the brain tissue to phorbol esters leads to the phosphorylation of a constituent that resembles the inhibitory guanine nucleotide binding protein. These findings suggest that the modulation of brain neurotransmitter responses may be mediated by activation of phospholipase A2 and/or protein kinase C, and that the critical factor in the modulatory response may be the phospharylation of a protein that regulates adenylate cyclase activity. Keywords: Brain chemistry; Cyclic AMP; Neuromodulation.
Descriptors : *BRAIN , *NEUROCHEMISTRY , *ADENOSINE PHOSPHATES , TISSUES(BIOLOGY) , PROTEINS , CHEMISTRY , RESPONSE , ANIMALS , INHIBITORS , ESTERS , MODULATION , CYCLIC COMPOUNDS , CENTRAL NERVOUS SYSTEM , AMINO ACIDS , NERVE TRANSMISSION , PHOSPHORYLATION , ADENYL CYCLASE , CORTICOSTEROID AGENTS , SYMPATHOLYTIC AGENTS , ISOPROTERENOL , BUTYRIC ACIDS
Subject Categories : Biochemistry
Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE