Accession Number : ADA174888


Title :   Chemical Preparation Laboratory IND Candidate Compounds.


Descriptive Note : Annual rept. 17 Jan 85-16 Jan 86,


Corporate Author : PHARM-ECO LABS INC SIMI VALLEY CA


Personal Author(s) : Schubert,Ernst M


Full Text : https://apps.dtic.mil/dtic/tr/fulltext/u2/a174888.pdf


Report Date : 21 Jan 1986


Pagination or Media Count : 35


Abstract : Six compounds were synthesized during the reporting period: 3-Beta-D-ribofuranoxyl-1(H)pyrazolo(4,3)-Dpyrimidin-7(6H)thione (Thioformycin-B); 9-Beta-D-ribofuranoxyl-purine-6-thiocarboxamide; 3-bromo-4-chloro-pyrazolo (3.4-d)pyrimidine; 2-Beta-D-ribofuranosylselenazo-4-caboxamide; cis, trans 3,6-diethoxy-tetrazadiphosphorine-3,6-disulfide; 1-Beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Ribavirin). The syntheses of ten target compounds have been examined during this annual period. The preparations of six of the ten target compounds were completed, and the compounds were transferred to USAMRIID, Department of Antiviral Studies. The syntheses of the four remaining target compounds, three of which are unreported in the chemical literature, are being further investigated.


Descriptors :   *SYNTHESIS(CHEMISTRY) , *ANTIVIRAL AGENTS , PREPARATION , CHEMICALS , ORGANIC COMPOUNDS , CHEMICAL LABORATORIES , ALKALOIDS , NUCLEOSIDES


Subject Categories : Pharmacology
      Organic Chemistry


Distribution Statement : APPROVED FOR PUBLIC RELEASE